Aliskiren in the treatment of renal disease; a narrative review

The renin–angiotensin–aldosterone system (RAAS) cascade has a significant effect on several systems. Angiotensin II (AngII) appeared as not only vasoactive peptide but also multifunctional cytokine that displays non-hemodynamic properties beyond renal hemodynamic properties. kidney includes total components of the RAAS such aldosterone and AngII adjust hemodynamics reabsorption sodium activating various inflammatory fibrotic responses. Inhibition is one most potent methods to impede development diseases chronic disease (CKD) its related problems high blood pressure heart disorders. Aliskiren, an octanamide, nonpeptide piperidine, orally, active, first commercially available, direct renin inhibitor (DRI), impedes operates by attaching active sites may be effective for management because blocking at point start sensitive step. Based numerous studies, aliskiren greatest powerful extents among inhibitors, even though it unable prevent (pro) receptor-mediated extracellular signal-regulated kinase 1 2 (ERK1/2) activations. In this review, described renoprotective effects against different types nephropathy acute injury, diabetic nephropathy, hypertensive nephropathy.